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  • Title: 6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: synthesis and antimicrobial activity.
    Author: Malinak D, Dolezal R, Marek J, Salajkova S, Soukup O, Vejsova M, Korabecny J, Honegr J, Penhaker M, Musilek K, Kuca K.
    Journal: Bioorg Med Chem Lett; 2014 Nov 15; 24(22):5238-41. PubMed ID: 25442318.
    Abstract:
    Quaternary ammonium salts substituted with a long alkyl chain exemplify a trustworthy group of medicinal compounds frequently employed as antifungal and antibacterial agents. A great asset of these surfactants underlying their widespread use is low local and system toxicity in humans. In this Letter, a series of novel quaternary 6-hydroxyquinolinium salts with varying length of N-alkyl chain (from C10 to C18) was synthesized and tested for in vitro activity against pathogenic bacterial and fungal strains. 6-Hydroxyquinolinium salt with C12 alkyl chain seems to be very interesting candidate due to a high antimicrobial efficacy and cytotoxic safety.
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