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  • Title: Corynanthean, eburnan, secoleuconoxine, and pauciflorine alkaloids from Kopsia pauciflora.
    Author: Gan CY, Yoganathan K, Sim KS, Low YY, Lim SH, Kam TS.
    Journal: Phytochemistry; 2014 Dec; 108():234-42. PubMed ID: 25442910.
    Abstract:
    Eleven indole alkaloids, comprising four corynanthean, two eburnane, one aspidofractinine, one secoleuconoxine, one andranginine, and two pauciflorine type alkaloids were isolated from the stem-bark and leaf extracts of Kopsia pauciflora. Their structures were determined using NMR and MS analyses. The catharinensine type alkaloid kopsirensine B and the secoleuconoxine alkaloid arboloscine A showed moderate to weak activity in reversing MDR in vincristine-resistant KB cells. The alkaloid content was markedly different compared to that of a sample from Malaysian Borneo.
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