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  • Title: Epidemiological profile of fungal keratitis in Sfax (Tunisia).
    Author: Cheikhrouhou F, Makni F, Neji S, Trigui A, Sellami H, Trabelsi H, Guidara R, Fki J, Ayadi A.
    Journal: J Mycol Med; 2014 Dec; 24(4):308-12. PubMed ID: 25442924.
    Abstract:
    UNLABELLED: Fungal keratitis is responsible for a significant burden of blinding disease in the developing world. OBJECTIVE: The aim of this study was to determine the etiological agents, predisposing factors and therapy of keratomycosis in our region. METHODS: Retrospective study of 60 patients with clinically and cultured confirmed fungi keratitis, who were attended at department of mycology in Sfax (1995 to 2012). RESULTS: The mean age of patients was 47.2 years (sex ratio: 1.58). At least, one presumed predisposing factor was identified in 83.3% of cases. Corneal traumatism was established as the most common predisposing factor (61.6%) with vegetative matter (42.4%). Patients had corneal ulcer in 40% or abscess in 47.6%. All cases were positive on direct microscopy and 93% of cultures were positive. Filamentous fungi form the major etiologic agents (83%): Fusarium species (49% with F. solani [66%]), Aspergillus sp. (22%), Alternaria (5%), Scedosporium sp. (2%); and non-identified mold in (5%). Yeast were identified in 17% of cases. Topical agents were used in 97% of cases: ketoconazole 2%, amphotericin B (0.5%). Fluconazole per os was administrated for 11% of cases, itraconazole (2 cases) and voriconazole (one case). Keratoplasty was indicated for 27% of cases. The outcome was favorable in 16% of patients. Among the patients, 71% had persistent corneal deposit sequelae. Four patients lost the eyeball. CONCLUSION: Corneal traumatism was the principal risk factor for fungal keratitis in young and middle-aged farmers. Fusarium solani is the predominant cause in Sfax. Early diagnosis, coupled with appropriate treatment, is crucial for increasing the chance of complete recovery.
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