These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Glutathione S-transferase M1 polymorphism and endometriosis susceptibility: a meta-analysis.
    Author: Li H, Zhang Y.
    Journal: J Gynecol Obstet Biol Reprod (Paris); 2015 Feb; 44(2):136-44. PubMed ID: 25443469.
    Abstract:
    BACKGROUND: Many studies have investigated the association between glutathione S-transferase M1 (GSTM1) null genotype and the risk of endometriosis. However, the effect of the GSTM1 null genotype on endometriosis is still unclear because of apparent inconsistencies among those studies. A meta-analysis was performed to characterize the relationship more accurately. PubMed, Embase, and Web of Science were searched. OBJECTIVE: To derive a more precise estimation of the relationship, a meta-analysis was performed. METHODS: We estimated the summary odds ratio (OR) with a 95% confidence interval (95% CI) to assess the association. Up to 24 case-control studies with 2,684 endometriosis cases and 3,119 control cases were included into this meta-analysis. RESULTS: Meta-analysis of the 24 studies showed that GSTM1 null genotype was associated with the risk of endometriosis (random effects OR=1.66, 95% CI 1.23 to 2.24). In the subgroup analysis by ethnicity, increased risks were found for both Caucasians (OR=1.26, 95% CI 1.04-1.51) and Asians (OR=1.28, 95% CI 1.06-1.55). No evidence of publication bias was observed. CONCLUSION: In conclusion, this meta-analysis suggests that the GSTM1 null genotype increases the overall risk of endometriosis.
    [Abstract] [Full Text] [Related] [New Search]