These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis and biological evaluation of ambradiolic acid as an inhibitor of glycogen phosphorylase.
    Author: Liu J, Zhang H, Zhu P, Wu X, Yao H, Ye W, Jiang J, Xu J.
    Journal: Fitoterapia; 2015 Jan; 100():50-5. PubMed ID: 25447165.
    Abstract:
    Ambradiolic acid (3) with oleanane skeleton is a natural pentacyclictriterpene. The first synthesis of 3 starting from 23-hydroxybetulinic acid (2) has been accomplished in 12-steps with a total yield of 18.1% in our study. Compound 3 was further biologically evaluated and found to exhibit significant inhibitory activity against rabbit muscle glycogen phosphorylase (GP) with an IC50 value of 12.4 μM, suggesting it could be a potential lead compound for the development of hypoglycemic drugs.
    [Abstract] [Full Text] [Related] [New Search]