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  • Title: [Ion conductance channels of bilayer from sarcoma-45 phospholipids].
    Author: Mirkhodzhaev UZ, Boldyrev VA, Tashmukhamedova AK, Tatarskiĭ VP, Dimant IN.
    Journal: Biofizika; 1989; 34(2):235-40. PubMed ID: 2545275.
    Abstract:
    Properties of black bilayer membranes formed from sarcoma-45 phospholipids differed from those of normal cell phospholipids bilayers. Two types of Ca2+-channels were discovered: those multiple to 35 pA and those multiple to 90 pA. The study of bilayers from phospholipids of nuclei, mitochondria, microsomal fractions showed that Ca2+-channels were localized in the microsomal fraction of transformed cells. The relationship between DB18C6 diacetylderivatives membrane activity and their effect to growth of sarcoma-45 in vivo was discovered: the Ca2+-channel blocker diacetyl-DB18C6 inhibited the transformed cells growth.
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