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  • Title: Communication between oocytes and somatic cells regulates volatile pheromone production in Caenorhabditis elegans.
    Author: Leighton DH, Choe A, Wu SY, Sternberg PW.
    Journal: Proc Natl Acad Sci U S A; 2014 Dec 16; 111(50):17905-10. PubMed ID: 25453110.
    Abstract:
    Males of the androdioecious species Caenorhabditis elegans are more likely to attempt to mate with and successfully inseminate C. elegans hermaphrodites that do not concurrently harbor sperm. Although a small number of genes have been implicated in this effect, the mechanism by which it arises remains unknown. In the context of the battle of the sexes, it is also unknown whether this effect is to the benefit of the male, the hermaphrodite, or both. We report that successful contact between mature sperm and oocyte in the C. elegans gonad at the start of fertilization causes the oocyte to release a signal that is transmitted to somatic cells in its mother, with the ultimate effect of reducing her attractiveness to males. Changes in hermaphrodite attractiveness are tied to the production of a volatile pheromone, the first such pheromone described in C. elegans.
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