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  • Title: Macrophage migration inhibitory factor in obese and non obese women with polycystic ovary syndrome.
    Author: Mejia-Montilla J, Álvarez-Mon M, Reyna-Villasmil E, Torres-Cepeda D, Santos-Bolívar J, Reyna-Villasmil N, Suarez-Torres I, Bravo-Henríquez A.
    Journal: Endocrinol Nutr; 2015 Jan; 62(1):31-7. PubMed ID: 25458401.
    Abstract:
    OBJECTIVE: To measure macrophage migration inhibitory factor (MIF) concentrations in obese and non-obese women diagnosed with polycystic ovary syndrome (PCOS). METHODS: Women diagnosed with PCOS and age-matched healthy controls with regular menses and normal ovaries on ultrasound examination were selected and divided into 4 groups (group A, PCOS and obese; group B, PCOS and non-obese; group C, obese controls; and group D, non-obese controls) based on body mass index (obese >30 kg/m2 and non-obese <25 kg/m2). Luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, sex hormone-binding globulin, serum glucose, insulin and MIF levels were measured. RESULTS: Obese and non-obese women with PCOS had higher luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, and insulin levels as compared to the obese and non-obese control groups, respectively (P < .0001). Women with PCOS had significantly higher MIF levels (group A, 48.6 ± 9.9 mg/ml; group B, 35.2 ± 6.0 ng/ml) as compared to controls (group C, 13.5 ± 6.0 ng/ml; group D, 12.0 ± 4.3 ng/dl; P < .0001). A weak, positive and significant correlation was seen between fasting blood glucose and insulin levels in women with PCOS (P < .05). CONCLUSION: Significant differences exist in plasma MIF levels between obese and non-obese women with and without PCOS.
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