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  • Title: Infants of opioid-dependent mothers: neurodevelopment at six months.
    Author: McGlone L, Mactier H.
    Journal: Early Hum Dev; 2015 Jan; 91(1):19-21. PubMed ID: 25460252.
    Abstract:
    OBJECTIVE: The aim of this study is to describe infant neurodevelopment in 81 infants of methadone-prescribed opioid-dependent mothers. METHODS: Griffith MD scores at six months. RESULTS: Scores were lower in all domains compared to controls (p<0.001). Poly-drug exposed infants and those treated for neonatal abstinence syndrome performed significantly poorer (p=0.002 and p=0.008 respectively). CONCLUSIONS: Infants of methadone-maintained opioid-dependent mothers show poorer neurodevelopment at six months of age than non-drug exposed comparison infants. Developmental difficulties are confounded by delayed visual development. PRACTICE IMPLICATIONS: These highly vulnerable children merit close surveillance throughout infancy. SUMMARY: Griffith MD scores at six months in 81 infants born to methadone-prescribed opioid-dependent mothers were lower in all domains compared to controls (p<0.001). Poly-drug exposed infants and those treated for neonatal abstinence syndrome performed significantly poorer (p=0.002 and p=0.008 respectively). Co-existing visual problems were common.
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