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  • Title: Synthesis and biological evaluation of 5'-glycyl derivatives of uridine as inhibitors of 1,4-β-galactosyltransferase.
    Author: Paszkowska J, Kral K, Bieg T, Żaba K, Węgrzyk K, Jaśkowiak N, Molinaro A, Silipo A, Wandzik I.
    Journal: Bioorg Chem; 2015 Feb; 58():18-25. PubMed ID: 25462623.
    Abstract:
    New 5'-glycyl derivatives of uridine containing fragments of varying lipophilicity were synthesized as analogues of natural peptidyl antibiotics. One of the studied compounds, 5'-O-(N-succinylglycyl)-2',3'-O-isopropylideneuridine (A4), showed moderate inhibition against 1,4-β-galactosyltransferase. However, additional studies showed that the observed inhibitory effect was due to binding to bovine serum albumin, which was used in assays as a stabilizer.
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