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  • Title: Langerhans cell histiocytosis presenting as hypothyroid goitre: a unique presentation.
    Author: Marupudi KC, Karanth SS, Thomas J.
    Journal: BMJ Case Rep; 2014 Dec 02; 2014():. PubMed ID: 25465459.
    Abstract:
    Langerhans cell histiocytosis (LCH) is a disease involving the antigen presenting cells, which can range from a single system involvement with an indolent course to a multisystem disease with increased morbidity. We present a rare case of LCH presenting as hypothyroid goitre that was successfully treated as per the LCH III trial protocol with a combination of vinblastine and oral prednisolone. We highlight the need for awareness of this rare presentation of LCH as a painless goitre which is often misdiagnosed as poorly differentiated thyroid carcinoma or overlooked as a benign disease.
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