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  • Title: Multiple types of logic gates based on a single G-quadruplex DNA strand.
    Author: Guo Y, Zhou L, Xu L, Zhou X, Hu J, Pei R.
    Journal: Sci Rep; 2014 Dec 04; 4():7315. PubMed ID: 25472865.
    Abstract:
    In this work, we demonstrate the use of a single DNA strand and G-quadruplex-specific dye NMM as a label-free switch for the construction of series of basic logic gates (YES, NOT, OR, INHIBIT, NOR, AND). The simple GT-rich sequence could be used to interact with several molecules (K(+), thrombin, Hg(2+), and Pb(2+)) to form different structures that can be distinguished by the label-free dye NMM. Our study showed that a single G-qudruplex DNA strand can function as multiple types of one-input and two-input logic gates with different combinations of input molecules.
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