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Title: Wilms' tumour and related syndromes. A unifying theory. Author: Côté GB. Journal: Ann Genet; 1989; 32(2):69-72. PubMed ID: 2547332. Abstract: The major role of somatic crossing-over in the aetiology of Wilms' tumour and other forms of cancer is emphasized. A model is proposed to show that tumour development is due to a cis-trans disruptive effect of somatic crossing-over on the maintenance of differential parental imprinting.[Abstract] [Full Text] [Related] [New Search]