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  • Title: A novel method for the preparation of a chiral stationary phase containing an enantiopure acridino-18-crown-6 ether selector.
    Author: Németh T, Lévai S, Fődi T, Kupai J, Túrós G, Tóth T, Huszthy P, Balogh GT.
    Journal: J Chromatogr Sci; 2015 Mar; 53(3):431-5. PubMed ID: 25477392.
    Abstract:
    This paper reports a novel method for the preparation of chiral stationary phases (CSPs) using an acridino-18-crown-6 ether selector as a model compound. Chiral stationary phase (R,R)-CSP- 2A: was obtained by in situ continuously recirculating the solution of carboxyl-substituted acridino-18-crown-6 ether (R,R)- 4: , dicyclohexylcarbodiimide and 3-(triethoxysilyl)propylamine through a high-performance liquid chromatography (HPLC) column containing blank silica gel in elevated pressure and temperature. The enantiomer separating ability of chiral stationary phase (R,R)-CSP- 2A: was investigated by HPLC using mixtures of enantiomers of 1-(1-naphthyl)ethylamine hydrogen perchlorate, 1-(2-naphthyl)ethylamine, 1-(4-bromophenyl)ethylamine and 1-(4-nitrophenyl)ethylamine hydrogen chloride. The best results were found for the separation of the mixtures of enantiomers of Br-PEA.
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