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  • Title: A new naphthoquinone and other antibacterial constituents from the roots of Xanthium sibiricum.
    Author: Chen WH, Liu WJ, Wang Y, Song XP, Chen GY.
    Journal: Nat Prod Res; 2015; 29(8):739-44. PubMed ID: 25482477.
    Abstract:
    Reinvestigating the chemical constituents of the roots of Xanthium sibiricum led to the isolation of a new naphthoquinone (1), together with 13 known compounds (2-14). Their structures were elucidated by using spectroscopic analyses, including HR-ESI-MS, 1D and 2D NMR, and by comparing their NMR data with those of related compounds. Compound 1 showed moderate antibacterial activity against Escherichia coli, Bacillus subtilis, Micrococcus tetragenus and Staphylococcus aureus, while 6 and 12 showed stronger antibacterial activity than the positive control ciprofloxacin against E. coli, with minimum inhibitory concentration values of 0.17 and 0.35 μg/mL, respectively.
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