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  • Title: Persistent viral DNA synthesis associated with an avian osteopetrosis-inducing virus.
    Author: Aurigemma RE, Comstock RD, Smith RE.
    Journal: Virology; 1989 Aug; 171(2):626-9. PubMed ID: 2548335.
    Abstract:
    Bone and red blood cell DNA was obtained from MAV-2(O) infected, osteopetrotic chickens and analyzed for the presence of integrated and unintegrated viral DNA. Results indicate that unintegrated MAV-2(O) DNA did not appear until after osteopetrotic lesions were well established. These observations lead us to conclude that, unlike some retroviral diseases, unintegrated viral DNA may not play a significant role in the pathogenesis of MAV-2(O) osteopetrosis. In addition, there was no evidence of a clonally derived tumor in the bone.
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