These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hospitalization with varicella and shingles before and after introduction of childhood varicella vaccination in Germany.
    Author: Siedler A, Dettmann M.
    Journal: Hum Vaccin Immunother; 2014; 10(12):3594-600. PubMed ID: 25483695.
    Abstract:
    In Germany, one dose of varicella vaccination has been recommended for children aged <24 months since 2004, and 2 doses have been recommended since 2009. Vaccination coverage (VC) is above 80% for one dose and 60% for 2 doses. In this study, data on varicella- and shingles-associated hospitalizations before and after vaccine introduction were assessed. Based on ICD-coded data of the main diagnosis of hospitalized cases from 1995-2012 in Germany, annual age-adjusted and age-specific hospitalization incidences (cases/100,000; HI) were calculated. HI means 1995-2003 (pre-vaccination-period) versus 2005-2012 (post-vaccination-period) were compared. Age-specific trends and annual percentage change rates (APC) were assessed by joinpoint regression. Overall age-adjusted varicella-HI decreased from 3.3/100,000 pre-vaccination to 1.9/100,000 post vaccination. The decline was greatest in regions with the highest VC. The post-vaccination decline was greatest in children aged <1, 1-4, and 5-9 y, who had APCs of -18.2,-27.2 and -15.2, respectively, and significant joinpoints. In all other age groups no post-vaccination joinpoints were detected or they did not lead to a consistent trend. Age-adjusted shingles-HI increased from 8.8/100,000 (1995) to 16.8/100,000 (2012). Shingles-HI increased in all age groups with no significant post-vaccination joinpoints, except in children<1 and 1-4 y, where APCs of -5.6 and -3.6 were detected. Varicella vaccination significantly reduced varicella-HI in children below 10 y, but was not definitely related to varicella-HI in older age groups. A consistent increase of shingles-HI began before varicella vaccination was introduced and was not affected by vaccination.
    [Abstract] [Full Text] [Related] [New Search]