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  • Title: Inhibition of superoxide anion radical production by ebselen (PZ51) and its sulfur analogue (PZ25) in guinea pig alveolar macrophages.
    Author: Leurs R, Timmerman H, Bast A.
    Journal: Biochem Int; 1989 Feb; 18(2):295-9. PubMed ID: 2548505.
    Abstract:
    The production of superoxide anion radicals by guinea pig alveolar macrophages is stimulated by the chemotactic peptide N-formylmethionyl-leucylphenylalanine and the protein kinase C activator phorbol-12-myristate-13-acetate. Both stimulations are completely and equipotently (IC50 = 20 microM) inhibited by the seleno-organic compound ebselen. As the sulfur containing analogue, which is devoid of glutathione peroxidase-like activity, shows the same inhibitory activity towards superoxide anion radical production the observed effect of ebselen can not be explained by the described glutathione peroxidase-like activity. The observed inhibition is probably caused by an inhibition of protein kinase C or inhibition at a level distal to protein kinase C activation.
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