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  • Title: Synthesis and in vitro antiplasmodial activity of ferrocenyl aminoquinoline derivatives.
    Author: Mwande Maguene G, Lekana-Douki JB, Mouray E, Bousquet T, Grellier P, Pellegrini S, Toure Ndouo FS, Lebibi J, Pélinski L.
    Journal: Eur J Med Chem; 2015 Jan 27; 90():519-25. PubMed ID: 25486423.
    Abstract:
    The aim of this study was to synthesize a series of ferrocenyl 4-aminoquinolines and to evaluate their activities against Plasmodium falciparum F32 (chloroquine-sensitive) and FCB1 and K1 (chloroquino-resistant). Some of the ferrocenyl compounds exhibited in vitro antiplasmodial activity in the nM range. In particular, (1R,4R)-N1-(7-chloroquinolin-4-yl)-N4-(ferrocenylmethyl)-N4-methylcyclohexane-1,4-diamine 17 presented the lowest IC50 value (26 nM) against CQ-resistant strains.
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