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  • Title: [Pharmacological action on emotional sphere with phenazepam and caffeine changes preference of ethanol in Wistar male rats].
    Author: Kulagina KO, Egorov AY, Filatova EV.
    Journal: Zh Evol Biokhim Fiziol; 2014; 50(2):130-6. PubMed ID: 25486818.
    Abstract:
    Earlier we have shown that essential for formation of preference to alcohol is not that much the initial anxiety level, but rather direction of its change in the process of forced alcoholization. The goal of this work was study of effect of change in the anxiety level on formation of action on the emotional sphere. Out of four groups, for 4 months of experiment, the 1st group had access only to the 10 % ethanol solution; the 2nd group--to the 10% ethanol with addition of 0.4 g/l caffeine; the 3rd - to 10% ethanol with 0.5 mg/l phenazepam; the 4th (control)--only to water. The anxiety level and behavioral parameters were estimated prior to the experiment and after each 5 weeks with aid of the test "the open field". Preference of ethanol was determined with aid of the test "the two-glass sample" before the experiment and each 4 weeks. In experimental groups of rats the long-term consumption of ethanol, of ethanol with caffeine, and of ethanol with phenazepam led to an increase in preference of alcohol as compared with control. A decrease of motor activity at the period of forced alcoholization was found to correlate positively with the low level of preference of alcohol. The rats consuming ethanol with caffeine and sensitive to action of the psychostimulator enhancing anxiety formed faster the preference to alcohol. In rats not sensitive to action of caffeine the preference to alcohol was not formed. Rats sensitive to the sedative action of phenazepam were less anxious and subsequently did not prefer alcohol. In rats not sensitive to phenazepam, anxiety was enhanced and preference to alcohol was formed.
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