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  • Title: Protein A-neutralizing monoclonal antibody protects neonatal mice against Staphylococcus aureus.
    Author: Thammavongsa V, Rauch S, Kim HK, Missiakas DM, Schneewind O.
    Journal: Vaccine; 2015 Jan 15; 33(4):523-6. PubMed ID: 25488332.
    Abstract:
    Staphylococcus aureus is a cause of sepsis and meningitis in very-low-birth-weight (VLBW) infants. Clinical trials with S. aureus specific antibodies failed to protect VLBW neonates, which may be due to the immune evasive attributes of staphylococcal protein A (SpA). Here we show that mouse monoclonal antibody SpAKKAA-mAb 3F6, which neutralizes the immunoglobulin Fcγ-binding and B cell receptor crosslinking attributes of SpA, protects neonatal mice against S. aureus sepsis and raises protective immunity against subsequent staphylococcal infection. We developed a humanized SpAKKAA-mAb that protects neonatal mice against S. aureus sepsis and may therefore be subjected to clinical testing in VLBW neonates.
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