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  • Title: Synthesis of OSW-1 derivatives by site-selective acylation and their biological evaluation.
    Author: Sakurai K, Takeshita T, Hiraizumi M, Yamada R.
    Journal: Org Lett; 2014 Dec 19; 16(24):6318-21. PubMed ID: 25490062.
    Abstract:
    A strategy to site-selectively monoacylate an antitumor saponin OSW-1 was developed using an organotin reagent to rapidly access its derivatives that are useful as chemical probes. 4″-O-Acylated OSW-1 derivatives bearing a fluorophore, an alkyne tag, or biotin were prepared in good yields and were shown to maintain highly cytotoxic activity.
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