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  • Title: Intravitreal chemotherapy provides control for massive vitreous seeding from retinoblastoma.
    Author: Lawson BM, Saktanasate J, Say EA, Shields CL.
    Journal: J Pediatr Ophthalmol Strabismus; 2014 Dec 12; 51 Online():e92-4. PubMed ID: 25490242.
    Abstract:
    Treatment of vitreous seeds in retinoblastoma is challenging because of relatively poor chemotherapeutic drug penetration by standard intravenous or intra-arterial routes. Intravitreal monotherapy with melphalan is effective but has a narrow therapeutic window. The authors describe a case of massive vitreous seeding successfully controlled after combination intravitreal chemotherapy using melphalan and topotecan with preserved anatomic outcome.
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