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  • Title: Quantum dots-hyperbranched polyether hybrid nanospheres towards delivery and real-time detection of nitric oxide.
    Author: Liu S, Gu T, Fu J, Li X, Chronakis IS, Ge M.
    Journal: Mater Sci Eng C Mater Biol Appl; 2014 Dec; 45():37-44. PubMed ID: 25491799.
    Abstract:
    In this work, novel hybrid nanosphere vehicles were synthesized for nitric oxide (NO) donating and real-time detection. The hybrid nanosphere vehicles consist of cadmium selenide quantum dots (CdSe QDs) as NO fluorescent probes, and the modified hyperbranched polyether (mHP)-based diazeniumdiolates as NO donors, respectively. The nanospheres have spherical outline with dimension of ~127 nm. The data of systematic characterization demonstrated that the mHP-based hybrid nanosphere vehicles (QDs-mHP-NO) can release and real-time detect NO with the low limit of 25 nM, based on fluorescence quenching mechanism. The low cell-toxicity of QDs-mHP-NO nanospheres was verified by means of MTT assay on L929 cells viability. The QDs-mHP-NO nanospheres provide perspectives for designing a new class of biocompatible NO donating and imaging systems.
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