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  • Title: [Effect of camptothecin on the DNA-relaxing and DNA-cleavage activity of calf thymus topoisomerase I].
    Author: Bronshteĭn IB, Gromova II, Bukhman VL, Kafiani KA.
    Journal: Mol Biol (Mosk); 1989; 23(2):491-501. PubMed ID: 2549395.
    Abstract:
    Nucleotide sequences that are cleaved by calf thymus type I topoisomerase have been determined using cloned human Ha-ras and p53 genes. Localization and relative frequency of single-strand cleavages within these sequences were observed to change in the presence of the cytotoxic alkaloid camptothecin.
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