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  • Title: Long-term effect of antidepressant drugs and electroconvulsive shock (ECS) on cortical alpha 1-adrenoceptors following destruction of dopaminergic nerve terminals.
    Author: Nowak G.
    Journal: Pharmacol Toxicol; 1989 May; 64(5):469-70. PubMed ID: 2549530.
    Abstract:
    The effect of repeated treatment with imipramine, citalopram and ECS on the density of alpha 1-adrenoceptors in the cerebral cortex of rats with a dopaminergic lesion was studied. Imipramine and citalopram produced alph 1-upregulation in normal animals but not in animals with a dopaminergic lesion. On the other hand, ECS, produced such an effect in both normal and lesioned rats. Our results indicate that the investigated drugs (imipramine, citalopram) and ECS induce alpha 1-up-regulation via different mechanisms, and that the effect of these drugs depends on intact dopaminergic nerve terminals.
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