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  • Title: Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion.
    Author: McCall TB, Boughton-Smith NK, Palmer RM, Whittle BJ, Moncada S.
    Journal: Biochem J; 1989 Jul 01; 261(1):293-6. PubMed ID: 2549965.
    Abstract:
    Stimulated rat peritoneal neutrophils release a platelet inhibitory factor with the pharmacological properties of NO. This release is inhibited by NG-monomethyl-L-arginine and L-canavanine, indicating that it occurs through a mechanism similar to that in vascular endothelial cells and macrophages. As the degree of stimulation increases, the factor released is progressively inactivated by concomitant release of superoxide anions.
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