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  • Title: Synthesis and fungistatic activity of aryl aldoxime derivatives.
    Author: Marek Gołębiewski W, Cyrta M, Michalczyk A.
    Journal: J Mycol Med; 2015 Mar; 25(1):50-6. PubMed ID: 25499806.
    Abstract:
    OBJECTIVE: The antifungal activity of 13 arylaldoxime ester and ether derivatives was tested against 4 dermatophytes Trichophyton mentagrophytes (TM), Microsporum canis (MC); M. cookei, and M. gypseum. MATERIALS AND METHODS: Structures of all new compounds prepared from aryl aldehydes were established by spectral means. The tests were performed on the Sabouraud Dextrose Agar (SDA) substrate. The sensitivity of the dermatophyte strains towards oxime derivatives was established by determining MIC and MFC values. RESULTS: The tested compounds showed a moderate fungicidal activity reaching 100% inhibition rate at 1% concentration. The activity against M. canis of 4 derivatives was higher than the activity of a reference drug clotrimazole. CONCLUSION: A novel group of biologically active compounds was introduced. Simple aldoxime derivatives can be developed into a new class of antifungals.
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