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  • Title: Radicals involved in photoallergen/protein interactions.
    Author: Delahanty JN, Evans JC, Rowlands CC, Barratt MD, Pendlington RU.
    Journal: Free Radic Biol Med; 1989; 7(3):231-6. PubMed ID: 2550330.
    Abstract:
    Aqueous solutions (pH = 8) of both 3,3'-dimethyl and 4,4'-dimethyl substituted analogues of the photoallergen fentichlor (bis(2-hydroxy-5-chlorophenyl)sulphide) produced stable semiquinone radicals when irradiated with u.v. light (greater than 310 nm). These radicals have been characterised using electron spin resonance techniques: the results confirm the assignment of hyperfine coupling constants for the parent fentichlor radical. The binding of fentichlor to HSA was found to be partly oxygen dependent demonstrating a role for semiquinone type radicals in the binding mechanism. The stoichiometry and specificity of the binding of the dimethyl analogues to soluble proteins were found to be similar to that of fentichlor itself.
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