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  • Title: Redox-neutral α-allylation of amines by combining palladium catalysis and visible-light photoredox catalysis.
    Author: Xuan J, Zeng TT, Feng ZJ, Deng QH, Chen JR, Lu LQ, Xiao WJ, Alper H.
    Journal: Angew Chem Int Ed Engl; 2015 Jan 26; 54(5):1625-8. PubMed ID: 25504920.
    Abstract:
    An unprecedented α-allylation of amines was achieved by combining palladium catalysis and visible-light photoredox catalysis. In this dual catalysis process, the catalytic generation of allyl radical from the corresponding π-allylpalladium intermediate was achieved without additional metal reducing reagents (redox-neutral). Various allylation products of amines were obtained in high yields through radical cross-coupling under mild reaction conditions. Moreover, the transformation was applied to the formal synthesis of 8-oxoprotoberberine derivatives which show potential anticancer properties.
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