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  • Title: Isolation and characterization of temperature-sensitive mutants of Abelson murine leukaemia virus that exhibit dissociation among morphological transformation, soft agar colony-forming ability and tyrosine kinase activity.
    Author: Oka Y, Sugiyama H, Tsukada S, Shimizu Y, Inoue H, Hakura A, Kishimoto S.
    Journal: J Gen Virol; 1989 Sep; 70 ( Pt 9)():2527-32. PubMed ID: 2550581.
    Abstract:
    Seven temperature-sensitive (ts) mutants of Abelson murine leukaemia virus (A-MuLV) were isolated on the basis of the temperature dependence of their soft agar colony-forming ability. These seven ts mutants exhibited similar characteristics and were not ts for morphological transformation and autophosphorylation of P120gag-abl protein. The dissociation of the properties of morphology, soft agar colony formation and tyrosine kinase activity might suggest that the v-abl product has more than one primary intracellular target.
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