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  • Title: Study of proton spin-lattice relaxation variation induced by paramagnetic antibodies.
    Author: Macrì MA, De Luca F, Maraviglia B, Polizio F, Garreffa G, Cavallo S, Natali PG.
    Journal: Magn Reson Med; 1989 Sep; 11(3):283-7. PubMed ID: 2550718.
    Abstract:
    A murine anti-human melanoma monoclonal antibody fragment was labeled with gadolinium and its proton relaxation efficiency compared to controls at frequencies ranging from 2 to 300 MHz. Relaxation time variations were about 30-40% in 10-15 microM solutions. The labeled fragment showed proton relaxation enhancement relative to free gadolinium, while preserving its immunoreactivity. A tentative labeling of a melanoma pellet by means of the fragment, just at the borderline of a minimum expected T1 variation, gave no detectable difference.
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