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  • Title: A potent and selective agonist for NK-2 tachykinin receptor.
    Author: Rovero P, Pestellini V, Patacchini R, Giuliani S, Santicioli P, Maggi CA, Meli A, Giachetti A.
    Journal: Peptides; 1989; 10(3):593-5. PubMed ID: 2550911.
    Abstract:
    Replacement of the glycine in position 8 of the C-terminal heptapeptide NKA(4-10) with beta-alanine give rise to a potent and selective agonist for the NK-2 tachykinin receptor. The affinity of [beta-Ala8]-NKA(4-10) to the NK-2 receptor is enhanced by almost one order of magnitude as compared to NKA(4-10), while affinity decreases at about the same extent at NK-1 and NK-3 receptors, respectively. Synthesis and biological activities of a series of NKA(4-10) analogues systematically replaced in each position with beta-alanine are also reported.
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