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  • Title: Identification of B2 bradykinin binding sites in the guinea pig nasal turbinate.
    Author: Fujiwara Y, Bloom JW, Mantione CR, Yamamura HI.
    Journal: Peptides; 1989; 10(3):701-3. PubMed ID: 2550915.
    Abstract:
    Specific high affinity BK binding sites in the nasal turbinate of the guinea pig have been demonstrated. Specific [3H]BK binding (10-330 pM) was saturable, and nonlinear least squares analysis indicated the presence of a high affinity binding site with a Kd value of 60 (50-78) pM and a Bmax value of 13.1 = 2.0 fmol/mg protein. In inhibition experiments, D-Phe7-BK (a B2 antagonist) inhibited [3H]BK binding with a Ki value of 23 nM, while des-Arg9[Leu8]-BK (a B1 antagonist) had no effect up to a concentration of 10 microM. These studies indicate the presence of B2 BK receptors in the guinea pig nasal turbinate.
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