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  • Title: [Adjuvant surgery to enhance therapeutic effects of chemo-embolization in advanced hepatocellular carcinoma].
    Author: Sasaki Y, Imaoka S, Shibata T, Wada H, Nagano H, Kameyama M, Ohigashi H, Hiratsuka M, Ishikawa O, Kabuto T.
    Journal: Gan To Kagaku Ryoho; 1989 Aug; 16(8 Pt 2):3045-8. PubMed ID: 2551245.
    Abstract:
    Different kinds of adjuvant surgery were carried out in three patients with advanced hepatocellular carcinoma (HCC) to enhance the therapeutic effects of chemo-embolization (TAE). The first patient, who had multiple foci localized in the right lobe, underwent ligation of the right portal vein in order to eliminate the small intrahepatic spreads and to protect against transportal metastasis to the left lobe. Afterward, TAEs were repeated a total of 5 times. The patient is still alive 24 months after the surgery with partial remission of the lesions. The second patient with severe cirrhosis had received TAE twice. Since one of the tumors, which existed in the hepatic hilus, did not respond to TAE, only the non-respondent tumor was removed surgically. This patient remains alive 28 months after the surgery with complete remission of the lesions. In the third patient, repeated TAEs resulted in collateral feeding arteries. Permanent decollateralization using silicone rubber sheeting was carried out following ligation of collaterals. Thus adjuvant surgery to enhance the therapeutic effects of TAE may be a significant palliative treatment for HCC.
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