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  • Title: Reversal of IgM deficiency following a gluten-free diet in seronegative celiac disease.
    Author: Montenegro L, Piscitelli D, Giorgio F, Covelli C, Fiore MG, Losurdo G, Iannone A, Ierardi E, Di Leo A, Principi M.
    Journal: World J Gastroenterol; 2014 Dec 14; 20(46):17686-9. PubMed ID: 25516687.
    Abstract:
    Selective IgM deficiency (sIGMD) is very rare; it may be associated with celiac disease (CD). We present the case of an 18-year-old man with sIGMD masking seronegative CD. Symptoms included abdominal pain, diarrhea and weight loss. Laboratory tests showed reduced IgM, DQ2-HLA and negative anti-transglutaminase. Villous atrophy and diffuse immature lymphocytes were observed at histology. Tissue transglutaminase mRNA mucosal levels showed a 6-fold increase. The patient was treated with a gluten-free diet (GFD) and six months later the symptoms had disappeared, the villous architecture was restored and mucosal tissue transglutaminase mRNA was comparable to that of healthy subjects. After 1 year of GFD, a complete restoration of normal IgM values was observed and duodenal biopsy showed a reduction of immature lymphocytes and normal appearance of mature immune cells.
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