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  • Title: Localization of human papillomavirus type 16 DNA using the polymerase chain reaction in the cervix uteri of women with cervical intraepithelial neoplasia.
    Author: Cornelissen MT, van den Tweel JG, Struyk AP, Jebbink MF, Briët M, van der Noordaa J, ter Schegget JT.
    Journal: J Gen Virol; 1989 Oct; 70 ( Pt 10)():2555-62. PubMed ID: 2552002.
    Abstract:
    The localization of human papillomavirus type 16 (HPV-16) DNA throughout the cervix uteri of women with cervical intraepithelial neoplasia (CIN) was studied by utilizing the polymerase chain reaction technique directly on histologically defined sections of paraffin-embedded cervical tissue obtained by conizations. HPV-16 DNA was detected only in the sections that contained CIN lesions and/or koilocytes. No HPV-16 DNA was detected in sections that contained only normal epithelium. This is in accordance with HPV-16 playing a role in the development of CIN lesions.
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