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  • Title: Intracellular localization of 99Tcm-d,l-HMPAO and 201Tl-DDC in rat brain.
    Author: Costa DC, Lui D, Sinha AK, Jarritt PH, Ell PJ.
    Journal: Nucl Med Commun; 1989 Jul; 10(7):459-66. PubMed ID: 2552362.
    Abstract:
    The intracellular localization and relative distribution of 99Tcm-hexamethylpropyleneamine-oxime (99Tcm-d, l-HMPAO) and 201Tl-diethyldithiocarbamate (201Tl-DDC), which have been used to assess regional cerebral blood flow (rCBF) in man, were investigated in rat brain. 99Tcm-d, l-HMPAO was found attached mainly to cell organelles whilst 201Tl-DDC was localized mainly in free state in the cytosolic fraction. Isolation of neuronal and glial nuclei showed that there is higher uptake of 99Tcm-d, l-HMPAO in neuronal nuclei than in glial nuclei for all the different regions of the rat brain investigated. These data demonstrate a different subcellular localization of the two lipophilic agents studied. In view of their proposed clinical utility, this difference merits further investigation.
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