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  • Title: Primary malignant melanoma of the ovary arising in a cystic teratoma; case report and review of the literature.
    Author: Lee J, Magpayo J, Panchari C, Peng SK.
    Journal: Dermatol Online J; 2014 Oct 15; 20(10):. PubMed ID: 25525997.
    Abstract:
    Primary malignant melanoma of the ovary arising in a cystic teratoma is extremely rare. There is no melanocytic component in the normal ovarian tissue. However, melanocytes may be present in a cystic teratoma of the ovary, especially at the basal layer of squamous epithelium. We report a case of primary malignant melanoma of the ovary arising in a cystic teratoma. We demonstrate junctional activity of melanocytes showing malignant transformation with both radial and vertical growth phases, a feature diagnostic for primary malignant melanoma but not always demonstrated in such cases. We compiled and reviewed twelve cases that are also able to demonstrate junctional activity.
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