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  • Title: Indeterminate cell histiocytosis that presented clinically as benign cephalic histiocytosis.
    Author: Haimovic A, Chernoff K, Hale CS, Meehan SA, Schaffer JV.
    Journal: Dermatol Online J; 2014 Dec 16; 20(12):. PubMed ID: 25526330.
    Abstract:
    Indeterminate cell histiocytosis (ICH) is a rare, heterogeneous disorder that is characterized by immunophenotypic features of both Langerhans cell histiocytosis (LCH) and non-LCH. We describe a 12-month-old boy with a four-month history of asymptomatic, small, pink-tan papules on his face. Histopathologic evaluation showed a superficial, dermal infiltrate of histiocytes that was positive for S100, CD1a, CD68, and Factor XIIIa. To our knowledge, this represents the first report of the clinical presentation of benign cephalic histiocytosis with immunohistochemical findings of ICH. We review the classification of histiocytic disorders and the clinical and immunohistochemical features of both ICH and benign cephalic histiocytosis.
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