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  • Title: α-Glucosidase inhibitors from the leaves of Embelia ribes.
    Author: Dang PH, Nguyen NT, Nguyen HX, Nguyen LB, Le TH, Do TN, Can MV, Nguyen MT.
    Journal: Fitoterapia; 2015 Jan; 100():201-7. PubMed ID: 25527005.
    Abstract:
    A novel and rare 1,4-dehydrated ceramide, embelamide (1), and a new C-glycoalkaloid which is based on a β-carboline ring system, 1-(2'-deoxy-α-d-ribopyranosyl)-β-carboline (4), were isolated from the CHCl3 soluble fraction of the leaves of Embelia ribes (Myrsinaceae), together with thirteen known compounds (2-3, 5-15). Their structures were elucidated on the basis of spectroscopic data. Compounds 1, and 5-12 possessed significant α-glucosidase inhibitory activity in a concentration-dependent manner, and showed more potent inhibitory activity, with IC50 values ranging from 1.3 to 155.0 μM, than that of a positive control acarbose (IC50, 214.5 μM).
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