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  • Title: The tumor marker score is an independent predictor of survival in patients with recurrent hepatocellular carcinoma.
    Author: Okamura Y, Ashida R, Ito T, Sugiura T, Mori K, Uesaka K.
    Journal: Surg Today; 2015 Dec; 45(12):1513-20. PubMed ID: 25527455.
    Abstract:
    PURPOSE: Alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) are prognostic factors for hepatocellular carcinoma (HCC). The impact of these tumor markers in recurrent HCC on the prognosis remains to be fully elucidated. METHODS: Two hundred and seventeen patients whose AFP and DCP levels were measured at recurrence were enrolled in the present study. AFP levels >10 ng/mL and DCP levels ≥40 mAU/mL were defined as AFP positive (AFP+) and DCP positive (DCP+), respectively. The patterns of tumor markers were scored as AFP-/DCP-, 0; AFP+/DCP- or AFP-/DCP+, 1 and AFP+/DCP+, 2. RESULTS: The median survival period after recurrence in patients with a score of 2 (26.6 months) was significantly lower than that in patients with scores of 1 or 0 (43.5 months, P < 0.01; 75.3 months, P < 0.01, respectively). A multivariate analysis showed that a tumor marker score of 2 at recurrence was an independent predictor for poor survival after recurrence (hazard ratio 2.12, P = 0.03). The prognosis after recurrence in the patients with a decreased tumor maker score was significantly better than that in the patients with no change in the tumor marker score compared to the primary surgery (P = 0.048). CONCLUSIONS: The present study shows that measurements of both AFP and DCP are useful for predicting the prognosis of recurrent HCC.
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