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  • Title: Preparation and physicochemical properties of chitosan broadleaf holly leaf nanoparticles.
    Author: Zhang H, Huang Q, Huang Z, Liu T, Li Y.
    Journal: Int J Pharm; 2015 Feb 01; 479(1):212-8. PubMed ID: 25528364.
    Abstract:
    OBJECTIVE: To prepare chitosan broadleaf holly leaf nanoparticles and to investigate their physicochemical properties and drug release characteristics in vitro. METHODS: Broadleaf holly leaf total flavonoids were extracted using an ethanol gradient and the determination of their contents was performed using a UV-vis spectrophotometer. Nanoparticles were prepared by ionic crosslinking. The morphology and distribution of the particles were examined. In addition, several factors affecting drug-loading and the encapsulation rate were explored. Furthermore, studies on the characteristics of in vitro release were performed. RESULTS: The content of total flavonoids from broadleaf holly leaf was 31.84%. The nanoparticles were spherical in shape, and the size range was between 100 and 600 nm. The polydispersity was 0.137. The optimal preparation process of the nanoparticles was the following: chitosan concentration 1 mg/ml, TPP concentration 1mg/ml, and concentration of broadleaf holly leaf total flavonoids 1 mg/ml. The in vitro release profile showed that the nanoparticles have an initial burst release effect of 45.6-48.9% within the first two hours. The total release was 91.9% in 24 h. CONCLUSIONS: Chitosan nanoparticles are a potential broadleaf holly leaf delivery system.
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