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  • Title: [Seroconversion with trivalent Sabin vaccine in children less than four years of age].
    Author: Díaz-Ortega JL, Valdespino-Gómez JL, Zárate-Aquino ML, Camacho-Amor ML.
    Journal: Bol Med Hosp Infant Mex; 1989 Aug; 46(8):517-25. PubMed ID: 2553055.
    Abstract:
    A group of 58 children under 4 years old, were vaccinated with trivalent oral poliovirus vaccine Sabin (OPV), in two sanitary areas of Chiapas, Mexico. The complement of procedures for the maintenance of the cold chain, and the changes in the potency of the vaccine prior and after the vaccination were evaluated. Nurses got a blood sample of 3cc and other one, four weeks after vaccination in order to evaluate the seroconversion rate attributable to Sabin vaccine, which was analyzed through neutralization serologic test. Moreover the investigation team got a sample of feces one day prior to vaccination and other one every week in the following three weeks to vaccination date in order to isolate the poliovirus in the feces of the children. The high pre-vaccination seropositivity suggests that in these areas exist a wide circulation of poliovirus, which probably were vaccine viruses and in less proportion wild viruses. The seroconversion rates were low for the three types of poliovirus, nevertheless 83% of the children had at least one of the three possibilities of seroconversion: unique, double or triple. Children with pre-vaccine seropositive probably had a secondary immune response.
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