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  • Title: Successful early rituximab treatment in a case of systemic lupus erythematosus with potentially fatal diffuse alveolar hemorrhage.
    Author: Na JO, Chang SH, Seo KH, Choi JS, Lee HS, Lyu JW, Nah SS.
    Journal: Respiration; 2015; 89(1):62-5. PubMed ID: 25531296.
    Abstract:
    Diffuse alveolar hemorrhage (DAH) is a rare but devastating complication of systemic lupus erythematosus (SLE) with a high early mortality rate. DAH seldom occurs without active organ involvement. Recently, rituximab (RTX), a B cell-targeted therapy, has been reported to be effective for life-threatening autoimmune diseases. We describe a SLE patient who presented with acute respiratory failure due to DAH without other active organ involvement. This condition was dramatically improved with RTX without cyclophosphamide.
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