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  • Title: Involvement of Holliday junction resolvase in fluoroquinolone-mediated killing of Mycobacterium smegmatis.
    Author: Long Q, Du Q, Fu T, Drlica K, Zhao X, Xie J.
    Journal: Antimicrob Agents Chemother; 2015 Mar; 59(3):1782-5. PubMed ID: 25534729.
    Abstract:
    The absence of the Holliday-junction Ruv resolvase of Mycobacterium smegmatis increased the bacteriostatic and bactericidal activities of the fluoroquinolone moxifloxacin, an important antituberculosis agent. The treatment of ruvAB-deficient cells with thiourea and 2,2'-bipyridyl lowered moxifloxacin lethality to wild-type levels, indicating that the absence of ruvAB stimulates a lethal pathway involving reactive oxygen species. A hexapeptide that traps the Holliday junction substrate of RuvAB potentiated moxifloxacin-mediated lethality, supporting the development of small-molecule enhancers for moxifloxacin activity against mycobacteria.
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