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  • Title: [Effect of several m-cholinoblockaders on the functioning of sodium potential-dependent channels of neuroblastoma cells].
    Author: Zubov AN, Grishchenko II, Nosyreva ED.
    Journal: Farmakol Toksikol; 1989; 52(4):17-20. PubMed ID: 2553477.
    Abstract:
    Effects of two central antimuscarinic drugs, namely N-methyl-4-piperidinol benzylate and tropine phenylcyclopentylglycolate on Na currents in internally dialyzed mouse neuroblastoma cells were studied using the suction-pipette voltage-clamp technique. Like amine local anesthetics, the both compounds produce two phenomenologically different types of sodium current inhibition: a steady block without conditioning and a cumulative (use-dependent) block which develops during repetitive membrane pulsing. The ability of these m-cholinoblockers to modulate voltage-dependent ionic permeability of the neuronal membranes is supposed to be one of possible components in the mechanism of their both main and accessory (non-synaptic) effects.
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