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  • Title: State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine" - research activities and scientific advance in 2013.
    Author: Bazyka D, Sushko V, Chumak A, Buzunov V, Talko V, Yanovych L.
    Journal: Probl Radiac Med Radiobiol; 2014 Sep; 19():14-25. PubMed ID: 25536544.
    Abstract:
    Research activities and scientific advance achieved in 2013 at the State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine" (NRCRM) concerning medical problems of the Chornobyl disaster, radiation medicine, radiobiology, radiation hygiene and epidemiology in collaboration with the WHO network of medical preparedness and assistance in radiation accidents are outlined in the annual report. Key points include the research results of XRCC1 and XPD gene polymorphism in thyroid cancer patients, CD38 gene GG genotype as a risk factor for chronic lymphocytic leukemia, frequency of 185delAG and 5382insC mutations in BRCA1 gene in women with breast cancer, cognitive function and TERF1, TERF2, TERT gene expression both with telomere length in human under the low dose radiation exposure. The "source-scattering/shielding structures- man" models for calculation of partial dose values to the eye lens and new methods for radiation risk assessment were developed and adapted. Radiation risks of leukemia including chronic lymphocytic leukemia in the cohort of liquidators were published according to the "case-control" study results after 20 years of survey. Increase of non-tumor morbidity in liquidators during the 1988-2011 with the maximum level 12-21 years upon irradiation was found. Incidence in evacuees appeared being of two-peak pattern i.e. in the first years after the accident and 12 years later. Experimental studies have concerned the impact of radio-modifiers on cellular systems, reproductive function in the population, features of the child nutrition in radiation contamination area were studied. Report also shows the results of scientific and organizational, medical and preventive work, staff training, and implementation of innovations. The NRCRM Annual Report was approved at the Scientific Council meeting of NAMS on March 3, 2014. Shhorichnyj zvit vidobrazhuje osnovni rezul'taty dijal'nosti Derzhavnoi' ustanovy „Nacional'nyj naukovyj centr radiacijnoi' medycyny Nacional'noi' akademii' medychnyh nauk Ukrai'ny” (NNCRM) z medychnyh problem Chornobyl's'koi' katastrofy, radiacijnoi' medycyny, radiobiologii', radiacijnoi' gigijeny ta epidemiologii', spivpraci z VO- OZ v merezhi medychnoi' gotovnosti ta dopomogy pry radiacijnyh avarijah u 2013 r. Osnovni rezul'taty doslidzhen' vkljuchaly doslidzhennja polimorfizmu geniv XRCC1 ta XPD u hvoryh na rak shhytopodibnoi' zalozy, genotypu GG gena CD38 jak faktoru ryzyku rozvytku hronichnoi' limfocytarnoi' lejkemii'; chastoty mutacij 185delAG ta 5382insC u geni BRCA1 u zhinok z rakom grudnoi' zalozy, kognityvnoi' funkcii' ta ekspresii' geniv TERF1, TERF2, TERT, ta dovzhyny telomer pry oprominenni ljudyny v intervali malyh doz. Rozrobleno modeli systemy „dzherelo–rozsijujuchi/ekranujuchi struktury–ljudyna” dlja rozrahunku parcial'nyh znachen' doz na kryshtalyk oka, adaptovano ta rozrobleno novi metody ocinjuvannja radiacijnyh ryzykiv. V kogorti uchasnykiv LNA opublikovano radiacijni ryzyky lejkemii', v tomu chysli hronichnoi' limfocytarnoi' za danymy doslidzhen' „vypadok-kontrol'” za 20 rokiv sposterezhennja. U likvidatoriv vstanovleno zrostannja uprodovzh 1988–2011 rr. nepuhlynnoi' zahvorjuvanosti z maksymal'nymy rivnjamy cherez 12–21 rokiv pislja oprominennja. Zahvorjuvanist' evakujovanogo naselennja maje dvi hvyli pidjomu – u pershi roky pislja avarii' ta cherez 12 rokiv. Eksperymental'ni doslidzhennja stosuvalysja vplyvu radiomodyfikatoriv na klitynni systemy, u naselennja vyvcheno stan reproduktyvnoi' funkcii', osoblyvosti dytjachogo harchuvannja na radioaktyvno zabrudnenyh terytorijah. U zviti takozh vidobrazheno rezul'taty naukovo-organizacijnoi', likuval'no-profilaktychnoi' roboty, pidgotovky kadriv ta vprovadzhennja. Zvit NNCRM zatverdzheno na zasidanni Naukovoi' rady NAMN Ukrai'ny 03.03.2014 r.
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