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Title: Late effects of ionizing radiation on functional status of bronchopulmonary system in COPD patients among the clean-up workers of the Chornobyl NPP accident.
Author: Sushko VO, Shvaiko LI, Bazyka KD.
Journal: Probl Radiac Med Radiobiol; 2014 Sep; 19():352-60. PubMed ID: 25536572.
Abstract:
The objective of the study was to determine the effects of ionizing radiation on the functional condition of the bronchopulmonary system in clean-up workers of Chornobyl NPP patients with COPD in a remote post-emergency period. Materials and methods. The study of functional characteristics was carried out in 272 patients - 197 clean-up workers of Chornobyl NPP accident (ChNPPA) with radiation exposure from 25 to 988 mSv; 75 - group of nosological control and 20 healthy persons. Results and conclusions. For the clean-up workers of Chornobyl NPP with exposure doses over 500 mSv demonstrated correlation between respiratory function parameters and dose which is confirmed for these patients, compared with irradiated in doses less than 500 mSv and nosology control, a significant decreasing of VC (76,3 ± 8,5%, 82,4 ± 8,5% and 82,7 ± 8,1% accordingly, p <0,05), FVC (78,2 ± 8,3%, 84,3 ± 7,9% і 86,1 ± 9,7%, p <0,05), FEF 50 (26,1 ± 11,5%, 32,6 ± 10,6% і 32,1 ± 12,7%, p <0, 05) і FEF 75 (23,8 ± 8,1%, 27,8 ± 9,3% і 27,6 ± 9,2%, p <0,05). These changers combined with decrease in lung diffusion capacity in cases more than 500 mSv, and indicate severe respiratory disorders in patients with COPD among clean-up workers of ChNPPA. Metoju doslidzhennja bulo vyznachyty efekty vplyvu ionizujuchogo vyprominjuvannja na funkcional'nyj stan bronholegenevoi' systemy v uchasnykiv likvidacii' naslidkiv avarii' na ChAES, hvoryh na hronichne obstruktyvne zahvorjuvannja legen' (HOZL) u viddalenomu pisljaavarijnomu periodi. Materialy ta metody doslidzhennja: provedeno vyvchennja funkcional'nyh harakterystyk u 272 pacijentiv – 197 uchasnykiv LNA z dozamy oprominennja vid 25 do 988 mZv, 75 – grupy nozologichnogo kontrolju ta 20 zdorovyh osib. Rezul'taty ta vysnovky. Dlja uchasnykiv likvidacii' naslidkiv avarii' na ChAES, oprominenyh v dozah bil'she 500 mZv, dovedena dozova zalezhnist' mizh pokaznykamy respiratornoi' funkcii' i dozoju oprominennja, shho pidtverdzhujet'sja dlja cyh hvoryh, v porivnjanni z oprominenymy u dozah menshe 500 mZv i nozologichnogo kontrolju, dostovirnym znyzhennjam pokaznykiv VC [(76,3 ± 8,5); (82,4 ± 8,5) i (82,7 ± 8,1) %, vidpovidno, p < 0,05], FVC [(78,2 ± 8,3); (84,3 ± 7,9) i (86,1 ± 9,7) %, p <0,05], FEF 50 [(26,1 ± 11,5); (32,6 ± 10,6) i (32,1 ± 12,7) %, p <0, 05] i FEF 75 [(23,8 ± 8,1); (27,8 ± 9,3) i (27,6 ± 9,2) %, p <0,05]. Ce u kompleksi zi znyzhennjam dyfuzijnoi' spromozhnosti legen' pry dozah, bil'shyh za 500 mZv, svidchyt' pro bil'sh vazhki respiratorni porushennja.

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