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  • Title: [Expression of chemokine receptor CXCR7 in gastric cancer tissues and cell lines].
    Author: Shi A, Dong L, Shi H, Jia M, Guo X, Jiang J, Qin B.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2014 Dec; 34(12):1780-4. PubMed ID: 25537902.
    Abstract:
    OBJECTIVE: To investigate the expression status of CXCR7 in gastric cancer tissues and cell lines. METHODS: The expression status of CXCR7 was detected in 35 primary gastric cancer tissues and matched adjacent tissues by immunohistochemistry and RT-PCR. The correlation of CXCR7 expression with the clinicopathological parameters and risk factors of gastric cancer was analyzed. The expression of CXCR7 in gastric cell lines (HGC-27, MGC-803, BGC-823, SGC-7901 and MKN-28) was also detected by immunofluorescence assay. RESULTS: The expression of CXCR7 was significantly higher in gastric cancer tissues than in adjacent tissues (P<0.01). CXCR7 expression was not correlated with age, gender, smoking history, Helicobacter pylori infection, tumor location or the pathological type, but showed a higher expression level in patients with a alcohol-drinking history than in those without (P<0.05). CXCR7 was expressed with variable intensities in the 5 gastric cancer cell lines without correlation with the degrees of cell differentiation; its expression was the highest in SGC-7901 cells, a moderately differentiated human gastric adenocarcinoma cell line. CONCLUSIONS: CXCR7 is highly expressed in gastric cancer tissues with variable intensities in 5 gastric cancer cell lines, suggesting its important role in gastric cancer progression.
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